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Sede
Social
Colegio Oficial
de Médicos
de Barcelona
Paseo de la Bonanova, 47
08017 Barcelona
Telf.: 93 863 02 38
Fax: 93 863 05 58
secretariaseacv@telefonica.net |
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Lunes, 23 de Enero de 2012
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| Publicación
Española del Mes Nº 13 |
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Son las 01:34:38 horas del 5-2-2012 |
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Archivo PDF
(98 KB)
Varicose Veins Show Enhanced Chemokine
Expression.
L. del Rio Solá, M. Aceves, A.I. Dueñas, J.A. González-Fajardo,
C. Vaquero, M. Sanchez Crespo, C. García-Rodríguez.
Article in press : Eur J Vasc Endovasc Surg (2009), doi:10.1016/j.ejvs.2009.07.021.
Vascular Surgery Division, Hospital Clinico Universitario, Valladolid, Spain
Instituto de Biología y Genética Molecular, CSIC-Universidad de Valladolid, Valladolid, Spain. cgarcia@ibgm.uva.es.
Factor de Impacto de Eur J Vasc Endovasc Surg : 3.007.
Objectives: Leucocyte infiltration in the wall of varicose veins has been reported previously. This study was designed to investigate the expression of pro-inflammatory cytokines and chemokines in control and in patients with varicose veins and to test the effect of
treating varicose vein patients with acetylsalicylic acid (ASA) on cytokine expression prior to removal of varices.
Material and methods: Sections of vein were removed during operation from both patient groups, and ribonuclease protection assays (RPAs) were performed to assess the expression of chemokines. Group I included non-varicose saphenous veins from healthy patients undergoing amputation for trauma. Varicose veins were obtained from patients with primary varicose undergoing surgical treatment who received no drug (group II) or treatment with 300 mg day_1 of ASA for 15 days before surgery (group III).
Results: Non-varicose veins constitutively expressed low levels of monocyte-chemoattractant protein (MCP-1) and interleukin (IL)-8 mRNA. Varicose veins had a distinct chemokine expression pattern, since significant up-regulation of MCP-1 and IL-8 and a marked expression of IP-10, RANTES, MIP-1a and MIP-1b mRNA were detected. Removal of the endothelium did not alter this pattern. Varicose veins obtained from patients treated with ASA showed a consistent decrease in chemokine expression, although it did not reach statistical significance.
Conclusions: Varicose veins showed increased expression of several chemokines compared to
control veins. A non-significant reduction of activation was observed following treatment with
ASA for 15 days.
2009 Published by Elsevier Ltd on behalf of European Society for Vascular Surgery.
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