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Sede
Social
Colegio Oficial
de Médicos
de Barcelona
Paseo de la Bonanova, 47
08017 Barcelona
Telf.: 93 863 02 38
Fax: 93 863 05 58
secretariaseacv@telefonica.net |
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Lunes, 23 de Enero de 2012
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| Publicación
Española del Mes Nº 7 |
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Son las 01:28:25 horas del 5-2-2012 |
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Archivo PDF
(453 KB)
The normal cellular prion protein and its possible
role in angiogenesis.
Marta Turu, Mark Slevin, Priya Ethirajan, Ana
Luque, AbdulBaset Elasbali, Angels Font, John Gaffney,
Marc Cairols, Pat Kumar, Shant Kumar, Jerzy Krupinski
J.
Frontiers in Bioscience 13, 6491-6500, May 1,
2008.
Department of Neurology, University Hospital of Bellvitge
(HUB), Fundacio IDIBELL, Barcelona, Spain, 2Cardiovascular
Research Centre, CSIC-ICCC, Hospital de la Santa Creu
i Sant Pau,Barcelona, Spain, 3School of Biology, Chemistry
and Health Science, Manchester Metropolitan University,
Manchester, UK, 4Department of Vascular Surgery, University
Hospital of Bellvitge (HUB), Barcelona, Spain, 4Department
of Pathology, Stopford building, University of Manchester,
United Kingdom.
TABLE OF CONTENTS
1. Abstract
2. Structure and synthesis of PrPc
3. Tissue localization and expression of PrPc
4. Functions of PrPc 4.1 .PrPc as a copper ligand 4.2
.PrPc protects against the oxidative stress 4.3 .PrPc
promotes cellular survival through signal transduction
4.4PrPc and antiapoptotic function 4.5 .Role of PrPc in
immune response 4.6 .Role of PrPc in angiogenesis: PrPc
expression in endothelial cells
5. References
1. ABSTRACT
Cellular Prion Protein (PrPc) is a ubiquitous glycoprotein
present on the surface of endothelial cells. Resting vascular
endothelial cells show minimum expression of PrPc and
can constitutively release PrPc. PrPc participes in cell
survival, differentiation and angiogenesis. During development,
neonatal brain endothelial cells transiently express PrPc.
Our group recently reported upregulation of PrPc in microvessels
from ischemic brain regions in stroke patients. Ischemia/hypoxia
induces PrPc expression through the activation of extracellular
signal-regulated kinase (ERK). All these data suggest
that PrPc plays an important role in angiogenic responses.
In addition, PrPc participates in cellular function in
the central nervous system, since PrPc is also highly
expressed in neurons. PrPc binds copper, suggesting a
role in copper metabolism. PrPc also protects cells against
oxidative stress and it seems to be involved in neuroprotection.
Several studies have demonstrated that PrPc prevents cells
from apoptosis and subsequent tissue damage. Moreover,
PrPc plays an important role in the immune response. Here,
we review the multiple functions of PrPc with a special
attention to its recently reported role in angiogenesis.
Artículo completo en formato PDF pulsando
AQUÍ.
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