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Sede
Social
Colegio Oficial
de Médicos
de Barcelona
Paseo de la Bonanova, 47
08017 Barcelona
Telf.: 93 863 02 38
Fax: 93 863 05 58
secretariaseacv@telefonica.net |
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Lunes, 23 de Enero de 2012
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| Publicación
Española del Mes Nº 9 |
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Son las 01:27:23 horas del 5-2-2012 |
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Archivo PDF
(58 KB)
Role of IL-10 promoter polymorphisms in the development
of severe aorto-iliac occlusive disease.
Blanco E, Moñux G, Mas A, Serrano FJ, de
la Concha EG, Urcelay E. Role.
Hum Immunol. 2008 Oct;69(10):651-4.
Unit of Angiology and Vascular Surgery, Hospital Universitario
de Guadalajara, Guadalajara, Spain
Factor de impacto (2007) de Hum Immunol. = 2.902.
Aortic severe occlusive disease (ASO) is a peripheral
manifestation of atherosclerosis with an inflammatory
component. Interleukin (IL)-10 is an anti-inflammatory
cytokine that plays a key role in the development of atherosclerosis,
promoting the stability of the atherosclerotic plaque.
Several polymorphisms within the 5' region of the IL-10
gene have been related to altered transcriptional activity
and protein levels. We aimed at studying two microsatellites,
IL-10R and IL-10G, at -4 and -1.2 Kb, and three single
nucleotide polymorphisms at positions -1082A/G, -819C/T
and -592C/A in a collection of 94 ASO patients and 519
ethnically matched controls. Our results show that the
IL-10 proximal promoter haplotype IL-10G*11/ -1082G/ -819C/
-592C is more frequent in ASO patients than in controls
(28.7% vs 16% p = 0.003; OR = 2.12). Therefore, our data
suggest a role of the IL-10 gene on ASO susceptibility.
the over-75s and among males, although the differences
were not statistically significant.
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